Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emetine myopathy: two case reports with pathobiochemical analysis.

H Sugie, R Russin, M A Verity

    Muscle & Nerve
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Spodoptera exigua: Capture of feral males in traps baited with blends of pheromone components.

    Journal of chemical ecology·2014
    Same author

    Identification of volatile sex pheromone components released by the southern armyworm,Spodoptera eridania (Cramer).

    Journal of chemical ecology·2013
    Same author

    Stereoisomers and analogs of 14-methyl-1-octadecene, sex pheromone of peach leafminer moth,Lyonetia clerkella, L.

    Journal of chemical ecology·2013
    Same author

    Host egg kairomones essential for egg-larval parasitoid,Ascogaster reticulatus Watanabe (Hymenoptera: Braconidae) : II. Identification of internal kairomone.

    Journal of chemical ecology·2013
    Same author

    Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans.

    International journal of obesity (2005)·2013
    Same author

    [Progress in the diagnoses and treatment for hereditary neurological and muscular disorders. Introductory remarks].

    No to hattatsu = Brain and development·2013
    Same journal

    Join AANEM.

    Muscle & nerve·2026
    Same journal

    Targeted Muscle Reinnervation for Management and Prevention of Symptomatic Neuroma.

    Muscle & nerve·2026
    Same journal

    AANEM News & Insights.

    Muscle & nerve·2026
    Same journal

    Fat-Fraction Quantification Using Three-Point Dixon Technique in Duchenne Muscular Dystrophy and Its Correlation With Clinical Progression and Genotypic Characteristics: A Single Centre One-Year Prospective Study.

    Muscle & nerve·2026
    Same journal

    Characterizing Combined Central and Peripheral Demyelination-Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis.

    Muscle & nerve·2026
    Same journal

    Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications.

    Muscle & nerve·2026
    See all related articles

    Emetine hydrochloride, used in aversion therapy, can cause reversible muscle weakness and damage in patients with alcohol abuse. Muscle biopsies revealed characteristic changes, including Z-band streaming and reduced mitochondrial content.

    Area of Science:

    • Neurology
    • Toxicology
    • Muscle Physiology

    Background:

    • Aversion therapy using emetine hydrochloride is employed for alcohol abuse treatment.
    • Alcohol abuse can predispose individuals to certain toxic exposures.
    • Proximal muscle weakness is a concerning symptom requiring investigation.

    Observation:

    • Two female patients with alcohol abuse history developed painful proximal muscle weakness after emetine hydrochloride therapy.
    • Muscle biopsies revealed distinct histopathological changes, including reversible loss of specific enzymes and Z-band streaming.
    • Electron microscopy showed mitochondrial reduction and normal sarcotubular systems.

    Findings:

    • Muscle biopsy in Case 1 demonstrated reversible floccular-shaped loss of myosin ATPase and dehydrogenase, with PAS-positive material accumulation.

    Related Experiment Videos

  • Repeat biopsy in Case 1 showed core changes without focal enzyme loss, indicating reversibility.
  • Case 2 exhibited similar, albeit milder, muscle biopsy changes, including Z-band streaming and decreased mitochondria.

    • Implications:

    • Emetine hydrochloride toxicity can manifest as a specific myopathy characterized by reversible enzymatic loss and structural changes.
    • Understanding these myopathic changes is crucial for diagnosing and managing patients undergoing emetine-based aversion therapy.
    • Further research into the precise mechanisms of emetine-induced myopathy and its long-term effects is warranted.