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Intravitreal 5-fluorouracil in the prevention of post-traumatic vitreous proliferation
Abstract:
We created double perforating injuries in both eyes of 24 rabbits. Into the vitreous cavity of one eye of each rabbit we injected 1 mg 5-fluorouracil (5-FU). After 2 months the eyes treated with 5-FU showed significantly less intraocular proliferation than the saline-treated control eyes.