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Related Experiment Videos

Fetal auditory brainstem evoked response (ABR).

J R Woods, M A Plessinger, C E Mack

    Pediatric Research
    |January 1, 1984
    PubMed
    Summary

    Auditory brainstem evoked responses (ABRs) in fetal lambs reveal that the auditory system matures significantly in late gestation. ABRs emerge by 117 days, with patterns approaching those of newborns by 126 days.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Auditory Neuroscience

    Background:

    • Auditory brainstem evoked responses (ABRs) are crucial for assessing auditory pathway function.
    • Understanding fetal auditory development is key to identifying potential hearing impairments early.

    Purpose of the Study:

    • To investigate the development of auditory brainstem evoked responses (ABRs) in fetal lambs.
    • To compare fetal ABRs with those of newborn lambs to understand auditory maturation.

    Main Methods:

    • Auditory brainstem evoked responses (ABRs) were recorded in fetal lambs instrumented in utero.
    • Fetal ABRs were compared with ABRs from term newborn lambs.
    • Recordings were taken at various gestational ages and days post-surgery.

    Main Results:

    • Fetal ABRs were absent before 117 days of gestation.
    • Reproducible ABRs emerged between 117-125 days gestation.
    • By 126 days gestation, ABR waveforms resembled those of newborns, albeit with delayed latencies, particularly between waves IV and V.

    Conclusions:

    • The fetal auditory system undergoes significant maturation during late gestation.
    • Decreasing latencies with advancing gestational age suggest an ongoing maturational process.
    • ABR development in fetal lambs provides insights into the timeline of auditory system development.

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