Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebellum: essential involvement in the classically conditioned eyelid response.

D A McCormick, R F Thompson

    Science (New York, N.Y.)
    |January 20, 1984
    PubMed
    Summary

    The dentate-interpositus nuclei in rabbits are crucial for associative learning, specifically the learned eyeblink response through classical conditioning. Damage to these nuclei abolishes the learned response, confirming their vital role.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development and evaluation of a standardized method and atlas for contouring primary and permanent dentition.

    Dento maxillo facial radiology·2015
    Same author

    Eyeblink conditioning leads to fewer synapses in the rabbit cerebellar cortex.

    Behavioral neuroscience·2009
    Same author

    The role of the cerebellum in classical conditioning of discrete behavioral responses.

    Neuroscience·2009
    Same author

    Dissociaton of conditioned eye and limb responses in the cerebellar interpositus.

    Physiology & behavior·2007
    Same author

    Slow adaptation in fast-spiking neurons of visual cortex.

    Journal of neurophysiology·2004
    Same author

    Cerebellar substrates for error correction in motor conditioning.

    Neurobiology of learning and memory·2001

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Learning and Memory

    Background:

    • Classical conditioning is a fundamental form of associative learning.
    • The cerebellum plays a role in motor learning and adaptation.
    • Understanding the neural basis of associative learning is key to cognitive neuroscience.

    Purpose of the Study:

    • To identify the specific neuronal structures responsible for classical conditioning of the eyelid response in rabbits.
    • To investigate the role of the dentate-interpositus nuclei and cerebellar cortex in associative learning.

    Main Methods:

    • Utilized classical conditioning to train rabbits for an eyelid response.
    • Performed targeted lesions of the dentate-interpositus nuclei and cerebellar cortex.
    • Recorded neuronal activity within the dentate-interpositus nuclei during learning.
    • Stimulated recording sites to observe behavioral output.

    Main Results:

    • Lesions of the ipsilateral dentate-interpositus nuclei completely abolished the learned eyeblink response.
    • Lesions of the cerebellar cortex did not affect the learned eyeblink response.
    • Neuronal recordings showed responses in the dentate-interpositus nuclei correlated with learning.
    • Stimulation of these nuclei elicited the conditioned eyelid response.

    Conclusions:

    • The dentate-interpositus nuclei are critically involved in both the learning and execution of classically conditioned eyelid responses.
    • These nuclei are essential for basic associative learning of discrete, adaptive behaviors.
    • The cerebellar cortex is not the primary structure mediating this form of associative learning.

    Related Experiment Videos