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Subacute salicylate intoxication in an infant with echovirus type 11 infection
Southern Medical Journal
|February 1, 1984
Insights
Echovirus 11 (E 11) infection in infants can be severe. A rare case combined E 11 with salicylate intoxication, leading to a fatal Reye's syndrome-like illness.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Toxicology
Background:
- Echovirus 11 (E 11) was a prevalent echovirus in the US in 1979.
- E 11 infections are known to cause severe illness in neonates.
Observation:
- A 5-week-old infant presented with E 11 infection.
- The infant also experienced subacute salicylate intoxication.
Findings:
- The combination of E 11 infection and salicylate intoxication resulted in a fulminant, fatal illness.
- The clinical presentation mimicked Reye's syndrome.
Implications:
- This case highlights a potentially lethal interaction between E 11 and salicylate toxicity in infants.
- Clinicians should consider this combination in infants presenting with severe, Reye's-like illness.
Abstract:
An antigenic variant of E 11 was the most frequently encountered echovirus in the United States in 1979. Several reports have indicated that infection with this agent was often associated with an overwhelming clinical course in neonates. Our case was in a 5-week-old infant with an E 11 infection complicated by subacute salicylate intoxication. This unfavorable combination resulted in a fulminant and fatal illness simulating Reye's syndrome.