Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simple method to predict digoxin serum concentration.

S W Shearer, W T Sawyer, S B Petteway

    Southern Medical Journal
    |March 1, 1984
    PubMed
    Summary

    Simple pharmacokinetic formulas accurately predict serum digoxin levels in patients. This method uses routine clinical data for reliable digoxin concentration estimation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan.

    Journal of clinical pharmacology·2001
    Same author

    Evaluation of outcomes in converting from intravenous ondansetron to oral granisetron: an observational study.

    The Annals of pharmacotherapy·2001
    Same author

    Perception of chemotherapy side effects cancer versus noncancer patients.

    Cancer practice·1999
    Same author

    Quality of life in patients surviving at least 12 months following high dose chemotherapy with autologous bone marrow support.

    Psycho-oncology·1999
    Same author

    Quality of life and preferences for treatment following systemic adjuvant therapy for early-stage breast cancer.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·1998
    Same author

    Clinical and economic impact of replacing divalproex sodium with valproic acid.

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·1997

    Area of Science:

    • Pharmacokinetics
    • Clinical Chemistry

    Background:

    • Digoxin is a critical medication for heart conditions.
    • Accurate monitoring of serum digoxin concentration is essential for therapeutic efficacy and safety.
    • Existing methods for predicting digoxin levels may require complex calculations or specialized data.

    Observation:

    • A retrospective study evaluated 35 hospitalized patients on oral digoxin maintenance therapy.
    • Serum digoxin concentrations were measured and compared to values predicted by simple pharmacokinetic formulas.
    • Routine clinical data was utilized for the prediction model.

    Findings:

    • The mean measured serum digoxin concentration (1.35 ng/ml) closely matched the mean predicted value (1.36 ng/ml).
    • A strong correlation (r = .82) was observed between measured and predicted digoxin concentrations.
    • Prediction accuracy was consistent between male and female patients.

    Implications:

    • Simple pharmacokinetic formulas provide a reliable and accessible method for predicting serum digoxin concentrations.
    • This approach can aid clinicians in optimizing digoxin therapy using readily available clinical information.
    • The findings support the integration of predictive pharmacokinetic modeling into routine patient care for digoxin management.

    Related Experiment Videos