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[Population genetics and the coagulation factor XIII A polymorphism].

C Rittner, T Wolf

    Zeitschrift Fur Rechtsmedizin. Journal of Legal Medicine
    |January 1, 1984
    PubMed
    Summary
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    This study analyzed Factor XIII A (FXIIIA) polymorphism in blood donors. The findings support FXIIIA as a useful genetic marker for paternity and linkage analysis in Caucasoid populations.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Hematology

    Context:

    • Platelets play a crucial role in hemostasis and thrombosis.
    • Understanding genetic variations in proteins involved in coagulation is essential for various applications.
    • Factor XIII A (FXIIIA) is a key component of the coagulation cascade.

    Purpose:

    • To determine the allele frequencies of the FXIII A polymorphism in a cohort of blood donors.
    • To evaluate the utility of FXIIIA as a genetic marker.

    Summary:

    • Agarose gel electrophoresis and immunofixation were used to genotype FXIII A polymorphism in 235 blood donors.
    • The observed allele frequencies (FXIIIA 1 = 0.7787, FXIIIA 2 = 0.2212) align with previous data for Caucasoid populations.
    • The study identified FXIIIA as a potential genetic marker.

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    Impact:

    • The findings contribute to population genetics data for FXIIIA.
    • FXIIIA polymorphism can serve as an additional valuable marker in paternity testing.
    • This genetic marker may also be beneficial for linkage studies in genetic research.