[Measurement of transmembrane potentials - a new method of in vitro tumor sensitivity testing]

Based on the idea that a relationship might exist between cell growth, cell metabolism and functional cell physiological parameters, particularly the bioelectrical membrane properties, the transmembrane potential (TMP) was measured on cultured ovarian tumour cells. After addition of cytostatic drugs to the cell cultures changes in TMP were observed, compared with the controls. The results clearly support that the TMP is a sensitive and objective measuring parameter in pretherapeutic sensitivity tests of tumours.