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Elevated serum selenium in diabetic children.

M Gebre-Medhin, U Ewald, L O Plantin

    Acta Paediatrica Scandinavica
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Diabetic children show significantly higher serum selenium levels compared to healthy children. This finding in pediatric diabetes may relate to altered lipid metabolism.

    Area of Science:

    • Pediatric Endocrinology
    • Nutritional Biochemistry
    • Trace Element Research

    Background:

    • Selenium is an essential trace element with antioxidant properties.
    • Altered lipid metabolism is a common complication in diabetes mellitus.
    • Previous research has not extensively investigated selenium status in diabetic children.

    Purpose of the Study:

    • To determine and compare serum selenium concentrations in diabetic children and healthy controls.
    • To explore potential correlations between serum selenium levels and diabetes indicators.

    Main Methods:

    • Serum selenium levels were measured in 27 diabetic children and 13 healthy controls using neutron activation analysis.
    • Participants were children aged 5-18 years with varying diabetes duration.

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  • Demographic data, growth patterns, and diabetes control indicators were recorded.

    • Main Results:

    • Diabetic children exhibited significantly higher mean serum selenium concentrations (7.4 ± 0.8 µg/100 ml) than healthy controls (6.5 ± 0.8 µg/100 ml).
    • The observed difference was statistically highly significant (p < 0.01).
    • No correlation was found between serum selenium levels and age, weight, height, or diabetes control indicators.

    Conclusions:

    • Diabetic children demonstrate elevated serum selenium levels compared to their healthy peers.
    • The elevated selenium may be linked to metabolic changes, particularly altered lipid metabolism, in pediatric diabetes.
    • Further research is warranted to elucidate the role of selenium in the pathophysiology of childhood diabetes.