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Pulmonary function in patients with endobronchial sarcoidosis
Acta Medica Scandinavica
|January 1, 1984
Summary
Sarcoidosis patients with airway obstruction often have bronchial sarcoidosis, with or without stenosis. Oral corticosteroids may improve lung function in these cases.
Area of Science:
- Pulmonary Medicine
- Respiratory Diseases
Background:
- Sarcoidosis is a multisystem inflammatory disease that can affect the airways.
- Bronchial involvement in sarcoidosis, including stenosis, can significantly impact lung function.
Purpose of the Study:
- To investigate the relationship between bronchial sarcoidosis, bronchostenosis, and lung function in sarcoidosis patients.
- To evaluate the impact of bronchodilators and corticosteroid treatment on lung function in these patients.
Main Methods:
- Bronchoscopy and spirometry (static and dynamic) were performed on 64 sarcoidosis patients.
- Patients were categorized based on the presence and severity of bronchial sarcoidosis and bronchostenosis.
Main Results:
- Nine patients had sarcoid bronchostenosis, showing marked lung function impairment, predominantly obstructive. Bronchodilators did not improve function.
- Three patients with stage II bronchial sarcoidosis without stenosis also exhibited obstructive patterns.
- Restrictive patterns were observed in stage II sarcoidosis patients without bronchostenosis.
- Lung function improved in five patients post-treatment, four with bronchostenosis and one without, with four receiving corticosteroids.
Conclusions:
- Clinical signs of airway obstruction in sarcoidosis warrant suspicion of bronchial sarcoidosis, with or without stenosis.
- Oral corticosteroid treatment should be considered for patients with bronchial sarcoidosis.