Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Thallium-201 scintigraphy in complete left bundle branch block.

H O Hirzel, M Senn, K Nuesch

The American Journal of Cardiology

|March 1, 1984

Summary

Left bundle branch block (LBBB) can cause false positives for coronary artery disease (CAD) on thallium-201 (TI-201) scans. This study shows LBBB can mimic ischemia due to asynchronous septal contraction, not necessarily CAD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Search for Higgs Boson and Observation of Z Boson through Their Decay into a Charm Quark-Antiquark Pair in Boosted Topologies in Proton-Proton Collisions at sqrt[s]=13 TeV.

Physical review letters·2023

Same author

Measurements of the Higgs boson production cross section and couplings in the W boson pair decay channel in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023

Same author

Probing Heavy Majorana Neutrinos and the Weinberg Operator through Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

Physical review letters·2023

Same author

Measurement of the mass dependence of the transverse momentum of lepton pairs in Drell-Yan production in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023

Same author

CMS pythia 8 colour reconnection tunes based on underlying-event data.

The European physical journal. C, Particles and fields·2023

Same author

Search for light Higgs bosons from supersymmetric cascade decays in <math></math> collisions at <math></math>.

The European physical journal. C, Particles and fields·2023

Area of Science:

Cardiology
Nuclear Cardiology
Diagnostic Imaging

Background:

Left bundle branch block (LBBB) can complicate the interpretation of myocardial perfusion imaging.
Anteroseptal perfusion defects are common in patients with LBBB, raising concerns for coronary artery disease (CAD).

Purpose of the Study:

To investigate whether LBBB itself can cause septal perfusion defects on thallium-201 (TI-201) exercise scintigraphy.
To differentiate between true CAD-induced ischemia and LBBB-induced artifacts in symptomatic patients.

Main Methods:

Evaluated 19 symptomatic patients with LBBB using TI-201 exercise scintigraphy and coronary arteriography.
Induce LBBB in dogs via right ventricular pacing and assessed TI-201 uptake and myocardial blood flow using radioactive microspheres.

Related Experiment Videos

Main Results:

Significant anteroseptal perfusion defects were observed in most LBBB patients, but only 4 had significant CAD.
In dogs, induced LBBB led to reduced septal TI-201 uptake (69%) and myocardial blood flow (89 ml/min/100 g) compared to the lateral wall.
These findings suggest LBBB can cause apparent septal ischemia.

Conclusions:

Symptomatic patients with LBBB may exhibit abnormal TI-201 exercise scintigrams suggestive of anteroseptal ischemia, even with normal coronary arteries.
Induced LBBB in dogs mimics these findings, indicating that septal perfusion defects in LBBB patients may result from asynchronous septal contraction rather than CAD.