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Nifedipine and the conditioning response.

D J Duffey, L D Horwitz, H L Brammell

    The American Journal of Cardiology
    |March 15, 1984
    PubMed
    Summary
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    Nifedipine did not inhibit exercise conditioning responses in healthy men. Both nifedipine and placebo groups showed significant improvements in VO2 max and exercise duration, indicating nifedipine does not blunt aerobic adaptations.

    Area of Science:

    • Cardiovascular Physiology
    • Exercise Science
    • Pharmacology

    Background:

    • Exercise conditioning significantly improves cardiorespiratory fitness.
    • Calcium channel blockers like nifedipine are used to manage cardiovascular conditions.
    • The impact of nifedipine on exercise adaptation requires further investigation.

    Purpose of the Study:

    • To determine if nifedipine affects the physiological adaptations to endurance exercise training.
    • To compare the effects of nifedipine versus placebo on maximal oxygen consumption (VO2 max) and exercise performance.

    Main Methods:

    • 14 healthy sedentary men aged 20-34 years participated.
    • Subjects were randomized to receive nifedipine (20 mg 3x daily) or placebo.
    • Both groups underwent 6 weeks of high-intensity exercise training (5x/week).

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    Main Results:

    • Both nifedipine and placebo groups demonstrated significant improvements in VO2 max and exercise duration.
    • Resting heart rate and rate-pressure product decreased significantly in both groups.
    • No significant differences were observed between the nifedipine and placebo groups for any measured outcome.

    Conclusions:

    • Nifedipine does not appear to inhibit the cardiorespiratory benefits of endurance exercise training.
    • Unlike other beta-blockers, nifedipine does not blunt the physiological response to exercise conditioning.
    • These findings suggest nifedipine can be safely used in individuals undergoing exercise training programs.