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Plasma cell iron--clinical and morphologic features.

T L McCurley, J B Cousar, S E Graber

    American Journal of Clinical Pathology
    |March 1, 1984
    PubMed
    Summary
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    Plasma cell iron, often linked to alcoholism, can occur across various iron storage levels. This iron is primarily found within plasma cells, even in extra-marrow tissues, and located in lysosomal vesicles.

    Area of Science:

    • Hematology
    • Pathology
    • Internal Medicine

    Background:

    • Plasma cell iron is a condition affecting iron distribution within plasma cells.
    • Its association with clinical conditions and specific cellular localization requires further elucidation.

    Purpose of the Study:

    • To identify the primary clinical features and laboratory findings in patients with plasma cell iron.
    • To investigate the cellular and subcellular distribution of iron in affected plasma cells.

    Main Methods:

    • Retrospective review of medical records and bone marrow aspirates from 53 patients with plasma cell iron.
    • Analysis of iron stores in bone marrow and extra-marrow tissues.
    • Ultrastructural examination of plasma cells for iron localization.

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    Main Results:

    • Plasma cell iron was most frequently associated with alcoholism.
    • It was observed across a spectrum of bone marrow iron stores (increased, normal, and decreased).
    • Ultrastructural studies confirmed iron localization within membrane-bound lysosomal vesicles in plasma cells.

    Conclusions:

    • Plasma cell iron is a distinct finding that can occur independently of other alcoholism-related bone marrow changes.
    • Iron in plasma cells can be detected in both bone marrow and extra-marrow sites.
    • The findings highlight the role of lysosomal vesicles in iron sequestration within plasma cells.