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Pulmonary edema associated with isoxsuprine therapy
American Journal of Obstetrics and Gynecology
|March 1, 1984
Summary
Parenteral isoxsuprine treatment can cause pulmonary edema in 0.5% of patients. Risk factors include anemia, multiple gestation, and excessive intravenous fluids, but the condition is reversible with standard medical care.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Critical Care Medicine
Background:
- Parenteral isoxsuprine is used in obstetric care.
- Pulmonary edema is a potential adverse effect of medications.
- Understanding risk factors for drug-induced complications is crucial.
Purpose of the Study:
- To determine the incidence of pulmonary edema in patients receiving parenteral isoxsuprine.
- To identify potential risk factors associated with this adverse event.
- To evaluate the effectiveness of treatment for isoxsuprine-induced pulmonary edema.
Main Methods:
- Retrospective review of 1,407 patient records.
- Analysis of patients treated with parenteral isoxsuprine over a 7-year period.
- Identification of cases with pulmonary edema and associated clinical factors.
Main Results:
- A 0.5% incidence of pulmonary edema was observed (7 out of 1,407 patients).
- Infusion rates were within normal limits in affected patients.
- Anemia, multiple gestation, and excessive intravenous fluids were identified as potential risk factors.
Conclusions:
- Parenteral isoxsuprine is associated with a low incidence of pulmonary edema.
- Prompt treatment including discontinuation of the drug, oxygenation, and diuretics/digoxin is effective.
- Awareness of risk factors can aid in prevention and early management.