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Related Experiment Videos

Form of the postsynaptic density. A serial section study.

R S Cohen, P Siekevitz

    The Journal of Cell Biology
    |July 1, 1978
    PubMed
    Summary
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    Researchers found perforations in postsynaptic densities (PSDs) in dog brain tissue. These holes, observed via serial sectioning, suggest novel structural features within synaptic junctions.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Histology

    Background:

    • Postsynaptic densities (PSDs) are crucial structures at neuronal synapses.
    • Previous research indicated potential complexities within PSDs.

    Purpose of the Study:

    • To investigate the detailed structure of postsynaptic densities (PSDs) in canine cerebral cortex.
    • To confirm and elaborate on earlier findings regarding PSD morphology.

    Main Methods:

    • Serial sectioning of dog cerebral cortex tissue was employed.
    • Microscopic analysis of serial sections cut parallel and normal to the synaptic junction plane.

    Main Results:

    • Perforations or holes were observed within larger postsynaptic densities (PSDs).

    Related Experiment Videos

  • These holes were present regardless of sectioning orientation relative to the synaptic junction.
  • Absence of synaptic cleft material opposite the hole and presynaptic membrane indentations were noted.
  • Clustering of presynaptic vesicles near the membrane opposite the PSD hole was observed.

    • Conclusions:

    • The study confirms the existence of perforations in canine cerebral cortex PSDs.
    • Associated morphological features suggest a specialized functional role for these PSD structures.
    • The precise functional significance of these observed holes and associated features remains to be elucidated.