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Related Experiment Videos

Infectious crystalline keratopathy.

D M Meisler, R H Langston, T J Naab

    American Journal of Ophthalmology
    |March 1, 1984
    PubMed
    Summary
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    Topical corticosteroid use may lead to unusual crystalline keratopathy caused by gram-positive cocci. This rare corneal condition can cause vision impairment despite treatment.

    Area of Science:

    • Ophthalmology
    • Microbiology

    Background:

    • Topical corticosteroids are widely used for ocular inflammation.
    • Unusual corneal opacities can arise from various etiologies, including infections.

    Observation:

    • Three male patients developed insidious, slowly progressive keratopathy with crystalline stromal opacities.
    • The condition was associated with topical corticosteroid use and minimal initial corneal inflammation.

    Findings:

    • Histopathology revealed gram-positive cocci in the corneal stroma in two patients.
    • Viridans streptococcus was isolated, with one strain identified as a dextran producer, potentially contributing to pathogenesis.
    • Despite treatment, residual scarring, neovascularization, and graft edema were observed.

    Implications:

    Related Experiment Videos

    • This study highlights a rare association between topical corticosteroid use, viridans streptococcus, and crystalline keratopathy.
    • Early recognition and microbiological investigation are crucial for managing this sight-threatening condition.
    • Dextran production by viridans streptococcus may play a role in the development of this specific keratopathy.