Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intradural morphine and diamorphine. Dose response studies.

G M Paterson, H J McQuay, R E Bullingham

    Anaesthesia
    |February 1, 1984
    PubMed
    Summary

    Intradural morphine and diamorphine provide effective postoperative analgesia in orthopedic surgery. Lower doses (0.625-1.25 mg) of these opioids, combined with cinchocaine, may be sufficient for managing pain, reducing the need for additional medication.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction to: Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy.

    BMC anesthesiology·2017
    Same author

    European Pain Federation position paper on appropriate opioid use in chronic pain management.

    European journal of pain (London, England)·2016
    Same author

    Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy.

    BMC anesthesiology·2016
    Same author

    Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty.

    British journal of anaesthesia·2016
    Same author

    A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine.

    European journal of pain (London, England)·2012
    Same author

    End-to-end military pain management.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2010

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Orthopedic Surgery

    Background:

    • Effective postoperative pain management is crucial following major orthopedic surgery.
    • Opioid administration via the intrathecal route offers targeted analgesia.
    • Optimizing opioid dosage and type is essential for balancing efficacy and side effects.

    Purpose of the Study:

    • To evaluate the duration of analgesia and side effects of varying intrathecal doses of morphine and diamorphine.
    • To determine the optimal dose range for intrathecal morphine and diamorphine in combination with cinchocaine for orthopedic surgery patients.

    Main Methods:

    • An open-label study involving 81 patients undergoing major orthopedic surgery.
    • Patients received intrathecal administration of morphine (0.625, 1.25, or 2.5 mg) or diamorphine (1.25 or 2.5 mg) with cinchocaine (7.5 mg) at anesthesia induction.

    Related Experiment Videos

  • Analgesia duration was assessed by the time to the first requirement for postoperative analgesia.

    • Main Results:

    • A significant dose-response relationship was observed for morphine, with higher doses (1.25 and 2.5 mg) providing longer analgesia than 0.625 mg.
    • No significant dose-response relationship was found for side effects with either opioid.
    • Diamorphine at 1.25 mg and 2.5 mg showed similar durations of analgesia, comparable to higher doses of morphine.

    Conclusions:

    • Intrathecal doses between 0.625 mg and 1.25 mg of morphine or diamorphine, when combined with cinchocaine, may be appropriate for postoperative analgesia in orthopedic surgery.
    • These lower doses, without additional parenteral opioids, could offer a balanced approach to pain management.
    • Further research may refine optimal intrathecal opioid regimens for specific surgical contexts.