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Summary
Polyurethane (PUR) coating on polyvinylchloride (PVC) tubing does not reduce di-2-ethylhexylphthalate (DEHP) migration during hemodialysis. In fact, PUR coating increased the release rate of DEHP into the blood.
Area of Science:
- Biomaterials Science
- Chemical Engineering
- Nephrology
Background:
- Polyvinylchloride (PVC) is a common material for extracorporeal circulation tubing.
- Di-2-ethylhexylphthalate (DEHP) is a plasticizer used in PVC, raising concerns about its migration into blood.
- Polyurethane (PUR) coating has been proposed to reduce DEHP transport.
Purpose of the Study:
- To investigate the effectiveness of PUR coating in reducing DEHP migration from PVC tubing used in hemodialysis.
Main Methods:
- Eight different types of PVC tubing sets for hemodialysis were analyzed.
- The migration of DEHP from the tubing sets was quantified over a 6-hour period.
Main Results:
- PVC tubing sets contained approximately 40% plasticizer by weight.
- Approximately 60 mg of plasticizer could be extracted from complete tubing sets over 6 hours.
- The release rate of DEHP from PUR-coated tubing was found to be higher compared to uncoated PVC.
Conclusions:
- Contrary to previous assumptions, PUR coating of PVC tubing is not effective in reducing DEHP migration.
- PUR coating may even increase the rate of DEHP release during hemodialysis procedures.