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Serial pattern shift visual evoked potentials in multiple sclerosis.

W J Becker, I M Richards

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |February 1, 1984
    PubMed
    Summary
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    In multiple sclerosis (MS) patients, visual pathway abnormalities measured by Pattern Stimulus Visual Evoked Potential (PSVEP) latency can worsen over two years, particularly in those with progressive disease or higher disability. Some eyes showed significant latency increases, even if initially normal.

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Clinical Neurology

    Background:

    • Multiple Sclerosis (MS) is a chronic neurological disease affecting the central nervous system.
    • Visual pathway dysfunction is common in MS, often assessed using Pattern Stimulus Visual Evoked Potentials (PSVEP).
    • Longitudinal changes in PSVEP latency can indicate disease progression or new demyelination.

    Purpose of the Study:

    • To evaluate changes in PSVEP positive peak latency over a two-year period in patients with MS.
    • To compare latency changes in MS patients with those in healthy controls.
    • To identify factors associated with significant PSVEP latency increases in MS.

    Main Methods:

    • Recalled 40 MS patients for repeat PSVEP testing after approximately two years.

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  • Tested 12 normal controls similarly over two-year intervals.
  • Analyzed changes in PSVEP positive peak latency, noting increases of 10 msec or more.

    • Main Results:

    • Normal controls showed minimal latency change (mean 1.4 msec).
    • Most MS patient eyes had minor latency changes; however, 18 eyes showed increases of 10 msec or more.
    • Significant latency increases were more frequent in patients with progressive/mixed MS courses, higher disability (Kurtzke 3-7), and occurred bilaterally more than expected by chance. Symptomatic eyes showed greater increases than asymptomatic ones. Latency increases occurred in both previously normal and abnormal eyes.

    Conclusions:

    • PSVEP latency can significantly increase over two years in MS patients, reflecting subclinical or clinical progression.
    • Disease course and disability level are associated with greater latency increases.
    • Repeat PSVEP testing is valuable for monitoring visual pathway changes in MS, even in eyes initially appearing normal.