Related Experiment Video
Updated: Aug 19, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 29, 2010
Alterations of glycosidases in benign, premalignant and malignant human lesions
Abstract:
Glycosidases were determined in the supernatant from normal, benign, premalignant, and cancerous human tissue. The total enzyme activities of alpha-fucosidase, hexosaminidase, beta-galactosidase, and acid phosphatase in both malignant tumors and tissues with premalignant lesions were significantly greater than those in normal tissues, whereas a very low enzyme activity alteration in benign lesions was observed. The least specific enzyme alteration was aryl sulfatase, which was elevated in only 58% of the tissues with malignancies and in 19% of the tissues with benign lesions. Nearly 90% of tissues with premalignant lesions had simultaneously elevated levels of two or more enzymes whereas only 5% of the control tissues had simultaneously elevated alpha-fucosidase, hexosaminidase, and acid phosphatase activity. Present results indicate that acid glycosidases have high activity in both premalignant and malignant human tissues.
Related Concept Videos
Protein Glycosylation
Glycosylation occurs in...
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Abnormal Proliferation
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Proteoglycans
Cellular Adaptation IV: Dysplasia and Metaplasia

