Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacokinetics in the 1980s.

L P Balant

    Clinical Therapeutics
    |January 1, 1984
    PubMed
    Summary

    Pharmacokinetics has advanced, focusing on drug variability and new models like population kinetics. These developments aid in creating better drugs and personalized patient treatments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Therapeutic drug monitoring databases for postmarketing surveillance of drug-drug interactions.

    Drug safety·2001
    Same author

    Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation.

    Therapeutic drug monitoring·2000
    Same author

    Modelling during drug development.

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2000
    Same author

    Cultural differences: implications on drug therapy and global drug development.

    International journal of clinical pharmacology and therapeutics·2000
    Same author

    Clomipramine concentration as a predictor of delayed response: a naturalistic study.

    European journal of clinical pharmacology·1999
    Same author

    Therapeutic drug monitoring of risperidone using a new, rapid HPLC method: reappraisal of interindividual variability factors.

    Therapeutic drug monitoring·1999

    Area of Science:

    • Pharmacology
    • Drug Metabolism and Pharmacokinetics

    Background:

    • Pharmacokinetics (PK) is a crucial scientific discipline.
    • Understanding drug behavior in the body is essential for drug development and patient treatment.

    Purpose of the Study:

    • To summarize achievements in pharmacokinetics.
    • To highlight current areas of interest and new developments in the field.
    • To discuss various pharmacokinetic models and their applications.

    Main Methods:

    • Discussion of compartmental and noncompartmental models.
    • Presentation of clearance models.
    • Exploration of population kinetics and integrated kinetic-dynamic models.

    Main Results:

    • Comparison of different pharmacokinetic models, including their advantages and drawbacks.
    • Identification of key areas of investigation, such as drug variability.
    • Emergence of new approaches for studying drug behavior in specific diseases (renal, hepatic) and in relation to genetic and environmental factors.

    Conclusions:

    • Pharmacokinetics is a fully accepted scientific discipline.
    • New concepts like population kinetics and integrated kinetic-dynamic models are vital for analyzing drug variability.
    • Advances in pharmacokinetics contribute to the development of improved drugs and personalized patient therapy.

    Related Experiment Videos