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Glucose perfusion intragastric titration.

V Maxwell, V E Eysselein, J Kleibeuker

    Digestive Diseases and Sciences
    |April 1, 1984
    PubMed
    Summary
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    Rabeprazole is superior to omeprazole for the inhibition of peptone meal-stimulated gastric acid secretion in Helicobacter pylori-negative subjects.

    Alimentary pharmacology & therapeutics·2003

    Glucose meals for gastric acid secretion measurement are effective and well-tolerated. This method, using intragastric titration, provides reliable comparisons of stimulated gastric acid secretion without significant side effects like diarrhea.

    Area of Science:

    • Gastroenterology
    • Physiology
    • Clinical Nutrition

    Background:

    • Accurate measurement of gastric acid secretion is crucial for diagnosing and managing gastrointestinal disorders, particularly peptic ulcer disease.
    • Traditional methods for gastric acid secretion assessment using intragastric titration have limitations, including potential side effects and accuracy issues.

    Purpose of the Study:

    • To compare the efficacy and tolerability of isotonic sodium chloride (saline) versus glucose solutions for intragastric titration in measuring gastric acid secretion.
    • To evaluate the suitability of glucose-enhanced intragastric titration for assessing both endogenous and exogenous gastrin-stimulated acid secretion in normal and duodenal ulcer subjects.

    Main Methods:

    • Intragastric titration was employed in normal and duodenal ulcer subjects using either saline or glucose solutions for gastric distention.

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  • Gastric acid secretion was measured continuously over a 3.5-hour period.
  • Circulating gastrin levels and acid secretion responses to endogenous peptone and exogenous G-17 stimulation were assessed.

    • Main Results:

    • Glucose distention did not significantly alter gastric acid secretion compared to saline distention in either subject group.
    • Glucose meals led to gastric acid secretion measurements with minimal side effects, notably avoiding the pronounced diarrhea observed with saline meals.
    • Glucose meals effectively inhibited gastric emptying, ensuring sufficient gastric volume for accurate continuous intragastric titration.

    Conclusions:

    • Glucose-enhanced intragastric titration is a reliable and well-tolerated method for measuring gastric acid secretion.
    • This technique allows for accurate comparisons of stimulated gastric acid secretion, proving particularly suitable for duodenal ulcer patients.
    • Glucose meals do not appear to alter gastrin sensitivity, supporting their use in studying gastrin-mediated acid secretion.