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HL-A antigens in pustular psoriasis.
Dermatologica
|January 1, 1977
Summary
Human Leukocyte Antigen (HLA) typing reveals HLA-B27 is elevated in specific pustular psoriasis subtypes, suggesting a link to arthritis and Reiter's disease. Psoriasis vulgaris and pustular psoriasis appear to be distinct conditions.
Area of Science:
- Immunogenetics
- Dermatology
- Rheumatology
Background:
- Pustular psoriasis encompasses several distinct clinical subtypes.
- The genetic associations of these subtypes, particularly with Human Leukocyte Antigen (HLA) antigens, are not fully elucidated.
- Understanding these associations may clarify etiological differences between psoriasis variants.
Purpose of the Study:
- To investigate the association of specific HLA antigens with different subtypes of pustular psoriasis.
- To compare HLA antigen frequencies in pustular psoriasis subtypes with those in psoriasis vulgaris and healthy controls.
- To explore potential etiological links between pustular psoriasis subtypes, arthritis, and Reiter's disease.
Main Methods:
- Human Leukocyte Antigen (HLA) typing was conducted on 97 patients diagnosed with various forms of pustular psoriasis.
- Patients were categorized into subgroups: localized psoriasis of palms and soles, acrodermatitis continua, and generalized pustular psoriasis.
- HLA antigen frequencies in these subgroups were compared to each other, to patients with psoriasis vulgaris, and to a control population.
Main Results:
- HLA-B27 was significantly increased in localized psoriasis of palms and soles, acrodermatitis continua, and generalized pustular psoriasis, correlating with a high incidence of arthritis.
- An increased frequency of HLA-Bw35 was observed in persistent palmo-plantar pustulosis.
- HLA-B13, HLA-B17, and HLA-Bw37, common in psoriasis vulgaris, were not elevated in the studied pustular psoriasis subtypes, except for 7 out of 30 patients with localized palmoplantar psoriasis.
Conclusions:
- The distinct HLA antigen profiles suggest that psoriasis vulgaris and pustular psoriasis are etiologically different entities.
- The elevated HLA-B27 in specific pustular psoriasis subtypes associated with arthritis indicates a potential shared pathogenesis with Reiter's disease.
- Some individuals with localized palmoplantar psoriasis may represent a distinct group with psoriatic predisposition to pustular reactions in these areas.