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Related Experiment Videos

Mouse ear PCA as a model for evaluating antianaphylactic agents.

N Inagaki, S Goto, H Nagai

    International Archives of Allergy and Applied Immunology
    |January 1, 1984
    PubMed
    Summary
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    Passive cutaneous anaphylaxis (PCA) in mouse ears is a sensitive model for studying allergic reactions. Ketotifen effectively suppressed this reaction, indicating its antianaphylactic potential.

    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • Passive cutaneous anaphylaxis (PCA) is a model for allergic reactions.
    • Assessing PCA in different skin sites is crucial for methodological refinement.

    Purpose of the Study:

    • To evaluate the ear as a site for eliciting PCA reactions.
    • To assess the efficacy of ketotifen in suppressing PCA.

    Main Methods:

    • PCA reactions were induced in the ears and dorsal skin of male ddY mice.
    • Dye leakage was measured to quantify the PCA reaction.
    • The effect of ketotifen on PCA was evaluated.

    Main Results:

    • PCA reactions in the ear were more sensitive and reproducible compared to the dorsal skin.
    • Ketotifen significantly suppressed the PCA reaction in the mouse ear.

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    Conclusions:

    • The ear is a suitable and sensitive site for studying PCA reactions.
    • Ketotifen demonstrates significant antianaphylactic activity in this model.