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Massive postmortem bronchoconstriction in guinea pig lungs.

Y L Lai, W J Lamm, D L Luchtel

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |February 1, 1984
    PubMed
    Summary
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    Postmortem guinea pig lungs exhibit a unique difficulty in inflation and deflation due to airway obstruction. This phenomenon, identified as bronchoconstriction, is triggered by endogenous constrictor agents released after death.

    Area of Science:

    • Pulmonary Physiology
    • Postmortem Lung Mechanics

    Background:

    • Postmortem changes in lung function are not fully understood.
    • A phenomenon of difficult lung inflation and deflation was observed in excised guinea pig lungs.

    Purpose of the Study:

    • To investigate the cause of impaired postmortem lung inflation and deflation in guinea pigs.
    • To identify the underlying mechanism of this postmortem lung phenomenon.

    Main Methods:

    • Studied 40 guinea pigs post-excision/exsanguination.
    • Assessed lung inflation/deflation dynamics and gas trapping.
    • Performed histological examination of airways.
    • Investigated the role of oxygen availability, temperature, vagotomy, and thromboxane inhibition (dazoxiben).

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    Main Results:

    • Less than 50% of lungs inflated at 30 min postmortem; significant gas trapping occurred.
    • Histology confirmed bronchoconstriction in bronchi and bronchioles.
    • Constriction onset was rapid (~5 min) and not O2-dependent.
    • Thromboxane inhibitor delayed constriction; temperature and vagotomy did not prevent it.

    Conclusions:

    • Postmortem bronchoconstriction is the likely cause of impaired lung inflation/deflation.
    • An endogenous constrictor agent appears to mediate this rapid postmortem airway narrowing.
    • Exsanguination influences the onset of postmortem bronchoconstriction.