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Computer methods for myocardial contrast two-dimensional echocardiography.

K Ong, G Maurer, S Feinstein

    Journal of the American College of Cardiology
    |May 1, 1984
    PubMed
    Summary
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    Computer-aided videodensitometry quantifies myocardial perfusion using contrast echocardiography. This method accurately detects changes in echo intensity, differentiating normal from ischemic tissue with high reproducibility.

    Area of Science:

    • Cardiovascular Imaging
    • Medical Physics
    • Echocardiography

    Background:

    • Two-dimensional contrast echocardiography is crucial for assessing myocardial perfusion.
    • Quantifying echographic opacification requires robust analytical methods.
    • Existing methods may lack precision in dynamic myocardial assessments.

    Purpose of the Study:

    • To evaluate two computer-aided videodensitometric methods for quantifying myocardial opacification.
    • To assess the time course of echographic signal changes after coronary artery contrast injections.
    • To determine the reproducibility and sensitivity of these methods in experimental settings.

    Main Methods:

    • Digitization of myocardial cross sections using a 128x128 resolution matrix.
    • Development of computer programs for time-intensity curve analysis (cardiac outline delineation, segmental division, regional intensity computation, exponential curve analysis).

    Related Experiment Videos

  • Application of stop-frame and continuous-cycle acquisition modes with Renografin-saline and sonicated sorbitol contrast agents in canine models.

    • Main Results:

    • The stop-frame method showed significant differences in echo intensity decay half-lives between normal (24±8s) and ischemic (293±165s) myocardium (p<0.001) for Renografin-saline.
    • High interobserver reproducibility (r=0.91, SE=5s) was achieved with the stop-frame method.
    • The continuous-cycle method yielded a mean half-life of 4.2±1.1s for sonicated sorbitol 70% in control states.

    Conclusions:

    • Computer-aided videodensitometry offers a quantitative approach to analyzing myocardial perfusion via contrast echocardiography.
    • These methods can effectively differentiate normal from acutely ischemic myocardium.
    • The developed techniques show potential for broad application in experimental studies of myocardial perfusion and function.