Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Repeated screening for breast cancer.

J Chamberlain, R E Clifford, B E Nathan

    Journal of Epidemiology and Community Health
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Design of an adaptive randomized clinical trial of intravenous citrulline for sickle cell pain crisis in the emergency department.

    Contemporary clinical trials communications·2023
    Same author

    Experiences of using the toll-free telephone line to access maternal and newborn health services in central Uganda: a qualitative study.

    Public health·2019
    Same author

    Effectiveness of progesterone, cerclage and pessary for preventing preterm birth in singleton pregnancies: a systematic review and network meta-analysis.

    BJOG : an international journal of obstetrics and gynaecology·2017
    Same author

    Airborne Emissions of Mercury from Municipal Landfill Operations: A Short-Term Measurement Study in Florida.

    Journal of the Air & Waste Management Association (1995)·2017
    Same author

    Seasonality of suicide behavior in Northwest Alaska: 1990-2009.

    Public health·2016
    Same author

    Seasonal cycle and regulation by temperature of antifreeze protein mRNA in a Long Island population of winter flounder.

    Fish physiology and biochemistry·2013

    Routine repeat breast cancer screening offers valuable insights, though sensitivity may decrease while specificity improves. Subsequent screens reveal fewer cancers but more benign results compared to initial screenings.

    Area of Science:

    • Oncology
    • Radiology
    • Public Health

    Background:

    • Routine screening mammography is crucial for early breast cancer detection.
    • Understanding the performance of screening tests over time is essential for optimizing patient outcomes.
    • High-risk populations may have different screening experiences compared to the general population.

    Purpose of the Study:

    • To compare the effectiveness of initial versus repeat screening mammography in high-risk women.
    • To evaluate changes in sensitivity, specificity, and biopsy yield in subsequent screening rounds.
    • To assess the prognostic outcomes for breast cancers detected during repeat screening.

    Main Methods:

    • Retrospective analysis of screening mammography results from a cohort of high-risk women.

    Related Experiment Videos

  • Comparison of diagnostic performance metrics (sensitivity, specificity) between first and subsequent screening examinations.
  • Analysis of the ratio of benign to malignant biopsies and cancer yield in initial versus repeat screens.

    • Main Results:

    • Sensitivity of breast cancer screening declined between the first and subsequent screens.
    • Specificity of screening improved with repeat examinations.
    • The ratio of benign to malignant biopsies worsened in repeat screens (21:1) compared to initial screens (6:1).
    • The yield of cancers decreased more significantly than the yield of benign findings in repeat screens.
    • Breast cancers diagnosed during the study had a favorable prognosis, with high survival and low recurrence rates.

    Conclusions:

    • While repeat screening improves specificity, the reduced cancer yield and increased benign biopsy ratio warrant careful consideration.
    • Early-stage breast cancers detected through screening, even on repeat exams, are associated with excellent long-term prognosis.
    • Further research may be needed to refine screening protocols for high-risk populations to balance sensitivity and specificity effectively.