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Related Experiment Videos

Amphotericin B fever in rabbits.

J C Arroyo

    Life Sciences
    |March 26, 1984
    PubMed
    Summary

    Slow intravenous infusion of amphotericin B (amB) caused fever in rabbits, with higher doses leading to more sustained fevers. Endotoxin-tolerant rabbits showed reduced fever responses to amB, while mice did not develop fever.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Immunology

    Background:

    • Amphotericin B (amB) is a critical antifungal agent.
    • Fever is a common side effect of intravenous drug administration.
    • Understanding pyrogenic responses to amB is crucial for patient safety.

    Purpose of the Study:

    • To investigate the pyrogenic effects of amphotericin B (amB) in rabbits.
    • To compare fever induction by slow infusion versus bolus injection of amB.
    • To determine the threshold pyrogenic dose of amB in rabbits.

    Main Methods:

    • Intravenous administration of amphotericin B (amB) to male adult rabbits via slow infusion and bolus injection.
    • Dose-ranging studies to identify pyrogenic thresholds.
    • Assessment of rectal temperature changes.
    • Evaluation of amB pyrogenicity in endotoxin-tolerant rabbits and mice.

    Main Results:

    • Slow intravenous infusion of amB induced a moderate, dose-dependent fever in rabbits.
    • Bolus injection of amB was less pyrogenic, requiring higher doses for fever induction.
    • The threshold pyrogenic dose of amB was approximately 0.16 mg/kg.
    • Endotoxin-tolerant rabbits exhibited a blunted febrile response to amB.
    • No fever was observed in mice treated with amB.

    Conclusions:

    • The route and rate of amphotericin B administration significantly influence its pyrogenic potential in rabbits.
    • Fever response to amB is dose-dependent and can be modulated by endotoxin tolerance.
    • Amphotericin B does not appear to be pyrogenic in mice.

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