Influence of parenterally administered amphetamine on the paroxysmal EEG activity in epileptics

Parenteral administration of d/l-amphetamine in higher doses had an activating or biphasic effect (i.e. activation was followed by inhibition) in the majority of examined patients. In the minority of patients a decreasing effect was obtained on the paroxysmal EEG activity in patients with various form of epilepsy. These results are in accord with animal experiments cited in the literature. It seems probable that the influence of amphetamine on epileptic phenomena in the brain is being mediated by specific mechanisms and not only by the non-specific activation of RAS. Hypotheses are proposed about the possible influence of the cerebellar and striatal mechanisms. The results of the experiment also contributed to clinical practice since the diagnosis could be clarified in several patients.