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Atopy, immunological changes, and respiratory function in bronchiectasis.

M B Murphy, D J Reen, M X Fitzgerald

    Thorax
    |March 1, 1984
    PubMed
    Summary
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    Bronchiectasis causes a hyperimmune response but not increased atopy, unlike cystic fibrosis. However, reversible airway obstruction was observed, suggesting bronchodilator use may be beneficial for patients with bronchiectasis.

    Area of Science:

    • Pulmonology
    • Immunology
    • Allergy

    Background:

    • Cystic fibrosis is linked to increased atopy and reversible airway obstruction.
    • Chronic suppurative lung infections may share similar features.
    • Bronchiectasis is a chronic suppurative lung disease.

    Purpose of the Study:

    • To investigate atopy and reversible airway obstruction in patients with bronchiectasis.
    • To compare these features in bronchiectasis patients to normal controls.
    • To understand the immunological response in bronchiectasis.

    Main Methods:

    • Studied 23 patients with bronchiectasis and 23 matched controls.
    • Assessed personal/family history of atopy and performed skinprick tests.
    • Measured blood eosinophil counts, serum IgE, immunoglobulins, and lung function (FEV1, FVC, PEFR).

    Related Experiment Videos

  • Evaluated reversibility of airflow obstruction after fenoterol inhalation.

    • Main Results:

    • Atopy prevalence was similar, but bronchiectasis patients showed stronger skin test reactions.
    • Significantly higher IgA levels were found in bronchiectasis patients.
    • Patients exhibited significant airflow obstruction (FEV1 67%, FVC 77%, PEFR 67%).
    • A reversible obstructive component was present in 9/23 patients after bronchodilator use.

    Conclusions:

    • Bronchiectasis induces a hyperimmune response but not a significant increase in atopy prevalence.
    • Reversible airway obstruction is a feature of bronchiectasis, similar to cystic fibrosis.
    • Bronchodilators may be a useful treatment adjunct for bronchiectasis.