Influence of phencyclidine on the translocation of pentobarbital in mice

The influence of phencyclidine (PCP) on the tissue distribution of pentobarbital in male Swiss mice (20-25 g) was investigated. Animals pretreated with PCP (179 mumol/kg/day) for 4 days, i.p., were administered pentobarbital (60 mg/kg, i.p.) 24 h after the PCP injection, sacrificed at various time intervals, and tissues (serum, brain, liver and kidney) were collected. Pentobarbital levels in tissues were determined by the gas liquid chromatography. When compared to the control group, PCP treatment decreased the pentobarbital level by 68% in liver and increased the level by 97% in kidney at 45 min post-injection. No significant change in serum and brain pentobarbital level was noted with either group. These data indicate that PCP influences the translocation of pentobarbital.