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[Acetylation processes in chronic alcoholics].

I E Kovalev, E N Kovalev, N G Seleznev

    Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
    |January 1, 1984
    PubMed
    Summary

    N-acetyltransferase activity in chronic alcoholics changes with disease stage. Rapid acetylators were common in early stages but significantly decreased in later stages of alcoholism.

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    Area of Science:

    • Pharmacogenetics
    • Enzyme kinetics
    • Alcoholism research

    Context:

    • Investigating the role of N-acetyltransferase (NAT) enzyme activity in chronic alcoholics.
    • Utilizing sulfadimezine acetylation intensity as a biomarker for NAT activity.
    • Examining variations in enzyme activity across different stages of alcoholic disease.

    Purpose:

    • To determine the correlation between N-acetyltransferase activity and the progression of chronic alcoholism.
    • To quantify the prevalence of 'rapid' and 'slow' acetylator phenotypes in different stages of alcoholism.

    Summary:

    • N-acetyltransferase activity was assessed in chronic alcoholics using sulfadimezine acetylation.
    • Stage II alcoholics showed a predominance of 'rapid' acetylators (60%).
    • A significant decline in 'rapid' acetylators (from 60% to 36%) was observed in Stage III disease.

    Impact:

    • Highlights potential pharmacogenetic differences in chronic alcoholics based on disease stage.
    • Suggests altered drug metabolism pathways in advanced alcoholism.
    • Provides insights into individual variability in response to medications metabolized by N-acetyltransferase.

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