Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toluene-induced decrease in rat plasma concentrations of tyrosine and tryptophan.

L Voog, T Eriksson

    Acta Pharmacologica Et Toxicologica
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The state of the art in beyond 5G distributed massive multiple-input multiple-output communication system solutions.

    Open research Europe·2023
    Same author

    Nighttime pasture access: Comparing the effect of production pasture and exercise paddock on milk production and cow behavior in an automatic milking system.

    Journal of dairy science·2019
    Same author

    The effects of high-sugar ryegrass/red clover silage diets on intake, production, digestibility, and N utilization in dairy cows, as measured in vivo and predicted by the NorFor model.

    Journal of dairy science·2017
    Same author

    Effects on milk urea concentration, urine output, and drinking water intake from incremental doses of potassium bicarbonate fed to mid-lactation dairy cows.

    Journal of dairy science·2014
    Same author

    Nuclear division in isolated protoplasts from cells of higher plants grown in vitro.

    Planta·2014
    Same author

    Transfer of algal chloroplasts into protoplasts of higher plants.

    Planta·2014

    Toluene exposure, via injection or inhalation, lowers rat plasma levels of tyrosine and tryptophan. These amino acids are crucial for neurotransmitter synthesis, potentially impacting brain function.

    Area of Science:

    • Neuroscience
    • Toxicology
    • Biochemistry

    Background:

    • Toluene is a common organic solvent with known neurotoxic effects.
    • Tyrosine and tryptophan are essential amino acids and precursors to vital neurotransmitters.
    • Amino acid transport into the brain can be influenced by plasma concentrations.

    Purpose of the Study:

    • To investigate the effect of toluene exposure on plasma concentrations of tyrosine and tryptophan in rats.
    • To explore the potential link between toluene-induced changes in amino acid levels and solvent-induced neurological effects.

    Main Methods:

    • Adult male Sprague-Dawley rats were exposed to toluene via intraperitoneal injection or inhalation.
    • Plasma concentrations of tyrosine and tryptophan were measured using validated analytical techniques.

    Related Experiment Videos

    Main Results:

    • Toluene exposure significantly decreased plasma concentrations of both tyrosine and tryptophan.
    • This effect was observed following both intraperitoneal injection and inhalation routes of exposure.
    • The reduction in plasma amino acids suggests a potential disruption in precursor availability for neurotransmitter synthesis.

    Conclusions:

    • Toluene exposure alters plasma levels of key amino acid precursors for neurotransmitters.
    • This biochemical change may contribute to the pathophysiology of toluene-induced neurotoxicity.
    • Further research is warranted to elucidate the precise mechanisms linking toluene, amino acid transport, and brain function.