Immunoproliferative small intestinal disease in Basenji dogs: morphologic observations

Eleven Basenjis with chronic diarrhea were evaluated for pathologic changes. Light microscopic and ultrastructural changes were characterized by lymphoplasmacytic infiltration of the lamina propria of the intestine and stomach and by evidence of degranulation of mast cells in close association with immunocytes. Other changes included hyperplasia of the thyroid parafollicular cells, thyroid follicular atrophy, epidermal atrophy, and ulceration of the pinna. Similarities of the condition in Basenjis and immunoproliferative small intestinal disease and Menetrier's disease in persons are presented.