Related Experiment Video
Updated: Aug 3, 2026

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
Published on: March 1, 2015
Recurrent isolated sixth nerve palsy in children
Insights
Recurrent sixth nerve palsy in children often lacks identifiable causes, challenging the notion that most cases are post-infectious. Further research is needed to understand this benign condition.
Area of Science:
- Ophthalmology
- Pediatric Neurology
Background:
- Sixth nerve palsy (also known as abducens nerve palsy) is a common cause of acute-onset strabismus in children.
- While often attributed to post-infectious or post-viral causes, the etiology of isolated sixth nerve palsy remains uncertain.
Observation:
- This study observed six children with recurrent sixth nerve palsy, averaging six weeks per episode.
- Recurrences were frequent, with an average interval of 1.3 years, and often occurred on the same side (ipsilateral).
Findings:
- No identifiable intracranial processes were associated with these recurrent palsies.
- The findings suggest that not all recurrent sixth nerve palsies in children are post-infectious, indicating a potentially larger group of 'benign' isolated cases than previously recognized.
Implications:
- The etiology of isolated, recurrent sixth nerve palsy in children remains largely unknown.
- This highlights the importance of considering recurrent sixth nerve palsy as a distinct entity, separate from single-episode palsies that may have more serious underlying causes.
- Diagnosis of benign sixth nerve palsy is retrospective, emphasizing the need for careful observation.
Abstract:
Six children had recurrent sixth nerve palsy the average duration of which was six weeks. One youngster, after several episodes of sixth nerve palsy, had residual esotropia and underwent strabismus surgery. The average interval between recurrences was 1.3 years. Ipsilateral recurrences were a prominent feature. Thus far the recurrences of palsy in this group of patients has not been associated with any identifiable intracranial process. Multiple recurrences in the absence of any recognizable febrile illness clearly suggests that not all "benign" sixth nerve palsies in children are due to postinfectious processes. The etiology of isolated benign sixth nerve palsy remains uncertain. Benign sixth nerve palsy with recurrence may account for a larger percentage of truly "isolated" palsies in otherwise healthy youngsters than has been generally appreciated since several widely quoted papers on this subject have included individuals with multiple neurologic deficits at the time of initial presentation. This report of recurrent palsies for which etiologies were not established should not diminish the concern that there might be an identifiable, serious, cause for sudden onset of sixth nerve palsy in a youngster. The diagnosis of "benign" sixth nerve palsy is one of exclusion that is made retrospectively and only after an adequate period of close observation.
More Related Videos
Related Concept Videos
Cranial Nerves: Overview and Anatomy
Cranial Nerves: Types Part I
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
Cranial Nerves: Types Part II
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Chickenpox
Poliomyelitis
Epilepsy ll: Types

