Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Silent otitis media: an animal study.

W L Meyerhoff, G S Giebink, D A Shea

    The Annals of Otology, Rhinology, and Laryngology
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Congenital dermoid cyst of the middle ear.

    Skull base surgery·2006
    Same author

    Microdialysis studies of the middle ear distribution kinetics of amoxicillin in the awake chinchilla.

    Journal of pharmaceutical sciences·2001
    Same author

    The prevention of pneumococcal disease in children.

    The New England journal of medicine·2001
    Same author

    A multi-laboratory evaluation of an enzyme-linked immunoassay quantitating human antibodies to Streptococcus pneumoniae polysaccharides.

    Immunological investigations·2001
    Same author

    Low cord blood pneumococcal antibody concentrations predict more episodes of otitis media.

    Archives of otolaryngology--head & neck surgery·2001
    Same author

    Otitis media prevention: non-vaccine prophylaxis.

    Vaccine·2001

    Silent otitis media, characterized by middle ear inflammation without visible eardrum changes, was confirmed in chinchillas. Histopathology revealed significant inner ear pathology despite normal-appearing tympanic membranes.

    Area of Science:

    • Otolaryngology
    • Pathology
    • Animal Models

    Background:

    • Otitis media can occur without apparent tympanic membrane abnormalities, termed silent otitis media.
    • This condition is increasingly recognized in clinical and laboratory settings.

    Purpose of the Study:

    • To investigate the histological evidence of silent otitis media in a pre-clinical animal model.
    • To compare middle ear pathology in animals exposed to otitis media-inducing conditions versus a control group.

    Main Methods:

    • Chinchillas were subjected to conditions predisposing to otitis media.
    • Temporal bone histopathology was performed on experimental and control groups.
    • Tympanic membranes were monitored using an operating microscope.

    Related Experiment Videos

    Main Results:

    • Histological examination revealed middle ear effusion, mucosal edema, granulation tissue, hyperemia, and polymorphonuclear leukocytes in the experimental group.
    • These pathological changes were absent in the control group.
    • Tympanic membranes in both groups appeared normal throughout the study.

    Conclusions:

    • Histopathological analysis confirms the existence of silent otitis media in chinchillas.
    • Otitis media can progress with significant middle ear pathology despite normal tympanic membrane appearance.
    • This animal model is valuable for studying silent otitis media pathogenesis and treatment.