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Related Experiment Videos

Effect of denervation on parotid gland function.

S L Levin

    The Annals of Otology, Rhinology, and Laryngology
    |March 1, 1984
    PubMed
    Summary

    Severed nerves in 110 subjects revealed distinct stages of salivation response to cholinergic agents. The atropine paradox demonstrated altered gland function following denervation, suggesting complex receptor interactions.

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    Area of Science:

    • Neuroscience
    • Physiology
    • Pharmacology

    Background:

    • Traumatic severance of secretory nerves impacts gland function.
    • Understanding denervation effects on salivation is crucial for nerve injury research.

    Purpose of the Study:

    • To investigate the functional changes in salivation following secretory nerve denervation.
    • To characterize the stages of altered cholinergic response in salivary glands.

    Main Methods:

    • Studied salivation in 110 subjects with severed secretory nerves.
    • Administered cholinergic agents and atropine to assess gland response.
    • Identified distinct stages of response including the atropine paradox.

    Main Results:

    • Observed an initial hyperpositive response to cholinergic agents, blocked by atropine (Stage I).
    • Documented reversal of atropine blockade with increased salivation in latent (Stage II) and overt (Stage III) forms of the atropine paradox.
    • Hypothesized the presence of at least five distinct cholinergic receptor populations on parotid membranes.

    Conclusions:

    • Denervation induces a complex, staged response in salivary gland function.
    • The atropine paradox highlights dynamic alterations in cholinergic receptor sensitivity post-nerve severance.
    • Parotid gland membranes likely possess multiple cholinergic receptor subtypes mediating differential responses.

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