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Bone mass in nodal primary generalised osteoarthrosis.
Annals of the Rheumatic Diseases
|April 1, 1984
Summary
This study found no significant difference in bone mass between women with generalized osteoarthritis and healthy controls. Bone mass is unlikely to be a key factor in the development of this condition.
Area of Science:
- Rheumatology
- Orthopedics
- Bone Metabolism
Background:
- Previous research indicated higher bone mass in hip osteoarthritis patients.
- Nodal primary generalized osteoarthritis exhibits a strong familial link, suggesting potential genetic influences on bone mass.
Purpose of the Study:
- To investigate if the familial tendency in nodal primary generalized osteoarthritis correlates with increased bone mass.
- To determine the role of bone mass in the pathogenesis of nodal primary generalized osteoarthritis.
Main Methods:
- Measured total body calcium using in-vivo neutron activation analysis in 15 female patients and 12 controls.
- Calculated cortical area from metacarpal indices.
- Matched controls for age, menopausal status, and skeletal size.
Main Results:
- No significant differences in total body calcium or cortical area were observed between patients and controls.
- Adjustments for skeletal size and menopausal status did not alter the findings.
- No correlation was found between radiological osteoarthritis grade and bone mass parameters.
Conclusions:
- Bone mass does not appear to be a significant factor in the aetiopathogenesis of nodal primary generalized osteoarthritis.
- The familial tendency in this condition may not be linked to increased bone density.