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Updated: Aug 14, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
The surgical treatment of tetralogy of Fallot
Insights
This review of 307 tetralogy of Fallot patients found that surgical outcomes depend more on right ventricle and pulmonary artery anatomy than patient age. This guides optimal surgical timing for congenital heart disease.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Surgery
Background:
- Tetralogy of Fallot (TOF) is a complex congenital heart defect.
- Surgical management of TOF has evolved, with varying approaches to complete repair versus palliative shunting.
- Optimal timing and strategy for TOF repair remain critical considerations.
Purpose of the Study:
- To review surgical outcomes for 307 patients with tetralogy of Fallot.
- To evaluate the impact of surgical policy changes on mortality.
- To identify key factors influencing the decision between palliative shunt and complete repair in TOF.
Main Methods:
- Retrospective review of 307 patients undergoing surgery for tetralogy of Fallot.
- Analysis of hospital mortality and late death rates.
- Evaluation of surgical strategies including complete repair and palliative shunts.
Main Results:
- A total of 301 patients underwent complete repair, while 6 received shunts.
- Overall mortality was 5.5% in patients under 12 years and 6.6% in those aged 12-20.
- Surgical policy shifted towards shunting infants <6 months and delaying complete repair until age 2.
Conclusions:
- Patient age is less critical than the anatomy of the right ventricular outflow tract and pulmonary arteries in determining surgical approach.
- Surgical strategy for tetralogy of Fallot should prioritize anatomical considerations over strict age guidelines.
- This study informs optimal surgical timing and decision-making for tetralogy of Fallot patients.
Abstract:
This is a review of the last 307 patients with tetralogy of Fallot who were operated on in our unit at Groote Schuur Hospital and Red Cross War Memorial Children's Hospital. Complete repair was undertaken in 301 patients, and shunts were performed in 6 children. There were 17 hospital deaths and 1 late death. The mortality was 5.5% for children less than 12 years old and 6.6% in patients between 12 and 20 years old. During this study period, there was a change in our policy as to when complete repair should be attempted. At present, we perform systemic-pulmonary shunts in patients less than 6 months old and delay complete repair until the child is 2 years old. In deciding whether a shunt should precede complete repair, our experience has shown that age is not as important a consideration as the anatomy of the outflow tract of the right ventricle and pulmonary arteries.
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