Sympathomimetic activity of mazindol on rat anococcygeus muscle and vas deferens
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Updated: Aug 14, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Abstract:
Mazindol contracted the isolated anococcygeus muscle of the rat. This effect was prevented by pretreatment with reserpine and antagonized by phentolamine but not by atropine, cocaine, hexamethonium, methysergide or promethazine. The drug potentiated the contractile response of the rat anococcygeus to noradrenaline and field stimulation and released tritium from the rat vas deferens and anococcygeus preloaded with [3H]-noradrenaline. The release of radioactivity was unaffected by incubation of the tissue in calcium free or high potassium (60 mM) solution.
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