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Related Experiment Videos

Is streptokinase safe during menses?

D L Simel, J R Moorman, S L Pryor

    Archives of Internal Medicine
    |April 1, 1984
    PubMed
    Summary

    Intravenous streptokinase effectively treated deep venous thrombosis in a woman during menstruation. This suggests streptokinase may be safe for thrombotic disorders occurring after the first day of menses.

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    Area of Science:

    • Cardiovascular Medicine
    • Hematology
    • Pharmacology

    Background:

    • Deep venous thrombosis (DVT) is a serious condition often requiring anticoagulant therapy.
    • Menstruation involves complex physiological changes in hemostasis.
    • The safety of thrombolytic agents during menstruation has been a concern due to potential bleeding risks.

    Observation:

    • A young woman presented with deep venous thrombosis during her menstrual period.
    • Intravenous streptokinase was administered for treatment.
    • Menstrual bleeding did not increase following treatment.

    Findings:

    • The patient experienced no increase in menstrual bleeding after streptokinase treatment.
    • The patient remained symptom-free from deep venous thrombosis six months post-treatment.
    • Menstrual hemostasis after the first day relies on arteriolar constriction, not primarily fibrin formation.

    Implications:

    • Streptokinase may be a viable treatment option for deep venous thrombosis occurring during menstruation, specifically after the first day.
    • These findings challenge the traditional contraindication of thrombolytic therapy during menses.
    • Further research is warranted to confirm the safety and efficacy of streptokinase in this patient population.

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