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Chromatographic separation and assay of morphine in tablets
Journal of Pharmaceutical Sciences
|August 1, 1978
Abstract:
A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recovery from standard solutions is greater than 99%. This method is more specific for the separation and determination or morphine in tablets than is the USP XVIII procedure.
Related Concept Videos
01:10Chromatography: Introduction
Chromatography is a technique used to separate compounds based on differences of partitioning between two phases, the stationary phase and the mobile phase.
The phase in which the compounds linger or on which the compounds adsorb is called the stationary phase, whereas the mobile phase is the solvent that carries the solutes to be analyzed. In traditional column chromatography, the mixture flows through the stationary phase, and the compounds partition between the stationary and mobile phases...
The phase in which the compounds linger or on which the compounds adsorb is called the stationary phase, whereas the mobile phase is the solvent that carries the solutes to be analyzed. In traditional column chromatography, the mixture flows through the stationary phase, and the compounds partition between the stationary and mobile phases...
01:12Chromatographic Methods: Classification
Chromatographic techniques are classified in three ways: the classification is based on the physical state of the stationary and mobile phases, how the mobile phase and the stationary phase contact each other, or through the chemical or physical processes that isolate the components of the sample. Typically, the mobile phase is either a liquid or gas, while the stationary phase is either a solid or a liquid layer applied to a solid surface.
Chromatographic techniques are typically named by...
Chromatographic techniques are typically named by...