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[Granulation tissue: inflammation and regeneration].

A B Shekhter, G N Berchenko, A V Nikolaev

    Arkhiv Patologii
    |January 1, 1984
    PubMed
    Summary
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    The body’s healing process can become pathological, leading to chronic wounds. This occurs when inflammation and regeneration become dissociated, creating a detrimental cycle.

    Area of Science:

    • Wound healing and tissue regeneration
    • Pathophysiology of chronic wounds

    Context:

    • Normal wound healing involves inflammation and regeneration, forming granulation tissue (GT).
    • Trophic disorders, burns, and radiation trauma disrupt healing mechanisms.
    • Impaired microcirculation and cell interactions hinder fibroblast proliferation and GT maturation.

    Purpose:

    • To explain the mechanisms behind the transformation of normal healing into pathological processes.
    • To identify factors contributing to the formation of abnormal granulation tissue and chronic wounds.

    Summary:

    • Adequate healing relies on coordinated inflammation and regeneration, forming functional granulation tissue.
    • Disruptions in healing lead to impaired fibroblast activity, abnormal extracellular matrix formation, and persistent inflammation.

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  • This dissociation results in a 'vicious circle' of non-healing wounds, ulcers, and chronic inflammatory conditions.

    • Impact:

    • Understanding these mechanisms is crucial for developing novel therapeutic strategies for chronic wounds.
    • This research highlights the importance of addressing underlying systemic and local factors in wound management.
    • Identifying the 'vicious circle' offers targets for interventions to restore effective tissue repair.