Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Relation between HLA and schizophrenia in German couples].

S Marras, M A Orfeo, S Zizolfi

    Bollettino Della Societa Italiana Di Biologia Sperimentale
    |February 28, 1984
    PubMed
    Summary

    Human Leukocyte Antigen (HLA) system genes may be linked to schizophrenia. While many siblings with differing schizophrenia status also differed in HLA type, identical twins with schizophrenia differences showed no HLA variation, suggesting a complex genetic relationship.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Titanium alloy response sensitivity to variations in spectral reconstructions of National Ignition Facility xenon line-emission x-ray sources.

    The Review of scientific instruments·2026
    Same author

    Measurements of K-edge and L-edge extended x-ray absorption fine structure at the national ignition facility (invited).

    The Review of scientific instruments·2024
    Same author

    The xenobiotic transporter <i>ABCC4</i>/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer.

    Frontiers in pharmacology·2024
    Same author

    The value of cardiopulmonary exercise testing and stress echocardiography in the prediction of all-cause mortality in adults with end-stage renal disease.

    European journal of sport science·2023
    Same author

    Intraspecific variation in thermal tolerance differs between tropical and temperate fishes.

    Scientific reports·2021
    Same author

    [The association of job satisfaction with self-reported burnout among urologists with migration background working at German hospitals : Results of the EUTAKD study].

    Der Urologe. Ausg. A·2021

    Area of Science:

    • Immunogenetics
    • Psychiatric Genetics

    Context:

    • Schizophrenia is a complex psychiatric disorder with a suspected genetic component.
    • The Human Leukocyte Antigen (HLA) system is a highly polymorphic region of the genome involved in immune response and has been investigated for associations with various diseases.

    Purpose:

    • To investigate the potential genetic linkage between the Human Leukocyte Antigen (HLA) system and schizophrenia.
    • To examine HLA antigen profiles in patients with schizophrenia and their siblings.

    Summary:

    • The study analyzed HLA antigens in patients with schizophrenia and their siblings.
    • In 11 out of 13 sibling pairs discordant for schizophrenia, differences in HLA type were observed, supporting a hypothesis of genetic linkage between HLA genes and schizophrenia.
    • However, one pair of identical twins discordant for schizophrenia did not show differences in HLA antigens, indicating a more complex genetic interaction than simple linkage.

    Related Experiment Videos

    Impact:

    • This research contributes to understanding the complex genetic architecture of schizophrenia.
    • Findings suggest that while HLA genes may play a role, other genetic or environmental factors are also critical in schizophrenia development.
    • Highlights the need for further investigation into the interplay of genetic factors in schizophrenia.