[Experimental pathogenicity of Cryptococcus cereanus in mice]

Pathogenicity studies in mice with Cryptococcus cereanus. Cr.cereanus, a yeast which showing a characteristic ability to grow above 40 degrees C, was found to induce pathogenicity when i.p. inoculated into mice after 6-7 repeated inoculations. Infected mice were sacrificed after 4, 8, 24 h and 3, 7, 14, 21 days following i.v. inoculation (5 X 10(7) cells); and microbiological, histopathological and blood-clinical tests were performed. The time course of C.F.U. in kidneys and brains (Fig.1) the yeasts colonization in heart and kidney tissues (Fig.5-3) and the characteristic "soap's balls" in brains (Fig.4) were confirmed by the modified serum levels of CPK, LDH, GOT, urea and creatinine. For the first time experimental pathogenicity of Cr. cereanus has been demonstrated.