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Related Experiment Videos

Premedication with butorphanol. A comparison with morphine.

D A Laffey, N H Kay

    British Journal of Anaesthesia
    |April 1, 1984
    PubMed
    Summary

    Butorphanol (2 mg) demonstrated comparable effectiveness to morphine (10 mg) for surgical premedication, offering fewer side effects. This study highlights butorphanol as a viable alternative for anesthesia preparation.

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    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Premedication is crucial for patient comfort and anesthesia management.
    • Morphine is a standard opioid for premedication, but can cause side effects.

    Purpose of the Study:

    • To compare the efficacy and safety of butorphanol versus morphine as a sole premedication for total abdominal hysterectomy.

    Main Methods:

    • A blind, comparative study involving 40 women undergoing hysterectomy.
    • Butorphanol (2 mg) and morphine (10 mg) were administered intramuscularly as premedication.
    • Subjective and objective measures were used to assess effectiveness and side effects.

    Main Results:

    • Butorphanol was found to be as effective as morphine based on subjective and objective assessments.
    • Butorphanol exhibited a favorable side effect profile compared to morphine.
    • No significant drug interactions were observed between butorphanol and fentanyl.

    Conclusions:

    • Butorphanol is a safe and effective alternative to morphine for premedication in gynecological surgery.
    • Further research is needed to refine anesthesia assessment scoring systems.

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