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Effect of halothane on lymph flow.

J G Whitwam, J R Pflug, M K Chakrabarti

    British Journal of Anaesthesia
    |April 1, 1984
    PubMed
    Summary
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    Halothane anesthesia significantly reduced thoracic duct lymph flow in dogs by 59%. Lymph flow returned to normal after discontinuing halothane, indicating its transient effect on lymphatic circulation.

    Area of Science:

    • Physiology
    • Anesthesiology
    • Lymphatic System Research

    Background:

    • The thoracic duct is the largest lymphatic vessel in the body, collecting lymph from most of the body.
    • Understanding factors affecting thoracic duct lymph flow is crucial for managing fluid balance and immune function.

    Purpose of the Study:

    • To investigate the effect of halothane anesthesia on thoracic duct lymph flow in dogs.
    • To quantify the changes in lymph flow during and after halothane administration.

    Main Methods:

    • Cannulation of the thoracic lymph duct in seven anesthetized, artificially ventilated dogs.
    • Measurement of baseline lymph flow.
    • Administration of 1% halothane and subsequent measurement of lymph flow.
    • Monitoring lymph flow after discontinuation of halothane.

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    Main Results:

    • The mean control lymph flow was 1.51 ml kg-1 h-1.
    • Halothane administration caused a 59% decrease in mean lymph flow (to 0.62 ml kg-1 h-1) within 20 minutes.
    • Lymph flow returned to control values 30 minutes after discontinuing halothane.

    Conclusions:

    • Halothane anesthesia significantly reduces thoracic duct lymph flow.
    • The effect of halothane on lymph flow is reversible upon discontinuation of the anesthetic agent.
    • These findings highlight the impact of anesthetics on lymphatic circulation and fluid dynamics.