Acute effects of tobacco smoking on blood flow in the cutaneous micro-circulation

p6 experimental model has been designed to help study the acute effects of tobacco smoking on the cutaneous micro-circulation. Arterioles in the nude mouse ear are directly visualised by intravital microscopy and the blood flow is quantified. Arteriolar vasoconstriction and decreased blood flow are seen in response to smoking. The implications of post-operative smoking for the patient undergoing flap surgery are discussed.