Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pentazocine-induced agranulocytosis.

H Haibach, Y W Yesus, J J Doggett

    Canadian Medical Association Journal
    |May 1, 1984
    PubMed
    Summary

    Pentazocine can cause agranulocytosis, a severe drop in white blood cells. This case is unique as it occurred without prior marrow-depressing treatments, highlighting a rare drug-induced condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Liver selenium and testis phospholipid hydroperoxide glutathione peroxidase are associated with growth during selenium repletion of second-generation Se-deficient male rats.

    The Journal of nutrition·1998
    Same author

    Micrometastasis in colorectal carcinoma: a review.

    Journal of surgical oncology·1998
    Same author

    Marked hyperlipasemia after radiotherapy in a patient with prostate cancer.

    Southern medical journal·1996
    Same author

    Apoptosis of gamma/delta T cells in human ehrlichiosis.

    American journal of clinical pathology·1996
    Same author

    Lymphocytosis of gamma/delta T cells in human ehrlichiosis.

    American journal of clinical pathology·1995
    Same author

    Growth and plasma triiodothyronine concentrations are modified by selenium deficiency and repletion in second-generation selenium-deficient rats.

    The Journal of nutrition·1995

    Area of Science:

    • Hematology
    • Pharmacology
    • Toxicology

    Background:

    • Agranulocytosis is a serious condition characterized by a severe deficiency of neutrophils.
    • Previous cases of agranulocytosis were often linked to myelosuppressive therapies like radiation and chemotherapy.
    • Understanding drug-induced agranulocytosis is crucial for patient safety and clinical management.

    Observation:

    • A 46-year-old male presented with a diagnosis of pentazocine-induced agranulocytosis.
    • The patient exhibited a complete absence of mature neutrophils in peripheral blood and bone marrow.
    • Notably, the patient had no history of predisposing factors such as radiation or antineoplastic drug use.

    Findings:

    • This case represents a unique instance of complete agranulocytosis.
    • The agranulocytosis was directly attributed to pentazocine, a potent analgesic.
    • The absence of other contributing factors underscores the specific toxicity of pentazocine in this individual.

    Implications:

    • This case highlights the potential for pentazocine to induce severe agranulocytosis even in the absence of typical risk factors.
    • Clinicians should consider pentazocine as a potential cause of agranulocytosis in patients presenting with neutropenia.
    • Further investigation into the mechanisms of pentazocine-induced myelosuppression may be warranted.

    Related Experiment Videos