Trisomy X as a possible initial chromosome change in a gastric cancer

Primary and metastatic gastric tumors from a patient previously treated for five different cancers were cytogenetically examined by G-banding. Both types of tumors had cells with a 47,XX, +X karyotype; in addition, the primary tumor had a second clone with a 48,XX, +X, +12 karyotype. No other abnormality was found in either tumor. The lymphocytes of this patient revealed a normal female diploid karyotype.